Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 14/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | TOP1 | P11387 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23722229 | 0.92 | HRH1 (0.40) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL23722322 | 0.90 | HRH1 (0.41) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL23721300 | 0.89 | HRH1 (0.43) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL23721409 | 0.88 | HRH1 (0.44) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL23721298 | 0.88 | HRH1 (0.43) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL23721301 | 0.87 | HRH1 (0.44) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL12930644 | 0.87 | HRH1 (0.56) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL23721027 | 0.87 | HRH1 (0.45) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL23721026 | 0.87 | HRH1 (0.42) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL23721268 | 0.86 | HRH1 (0.44) | HRH1KCNH2CHRM1ADRA2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445343-B1 | PRODRUGS OF NH-ACIDIC COMPOUNDS | ALKERMES PHARMA IRELAND LTD (IE) | 2021-08-04 | — | — | EP | disclosed |