Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.72 |
| ▸ | CTSD | P07339 | 16/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016855 | 0.84 | BACE1 (1.00) | BACE1CTSDKCNH2 | |
| SCHEMBL15418818 | 0.83 | BACE1 (0.86) | BACE1CTSDKCNH2 | |
| SCHEMBL10285176 | 0.82 | BACE1 (0.71) | BACE1CTSD | |
| SCHEMBL2371106 | 0.82 | BACE1 (0.75) | BACE1CTSD | |
| SCHEMBL2371095 | 0.82 | BACE1 (0.75) | BACE1CTSD | |
| SCHEMBL2519923 | 0.82 | BACE1 (0.80) | BACE1CTSD | |
| SCHEMBL2519918 | 0.82 | BACE1 (0.80) | BACE1CTSD | |
| SCHEMBL2371317 | 0.77 | BACE1 (0.64) | BACE1CTSD | |
| Trifluoroacetic Acid SCHEMBL15063400 | 0.77 | BACE1 (0.65) | BACE1CTSDKCNH2 | |
| SCHEMBL2371065 | 0.74 | BACE1 (0.64) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547685-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |