Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6712056 | 0.79 | GABRR1 (0.47) | SMN1; SMN2GAAMAPTKDM4ERAB9A | |
| SCHEMBL13765710 | 0.69 | GAA (0.39) | SMN1; SMN2GAAMAPTHSP90AB1CYP4F2 | |
| SCHEMBL2143331 | 0.68 | KDM4E (0.49) | SMN1; SMN2MAPTKDM4ERAB9ANPC1 | |
| SCHEMBL6712382 | 0.67 | — | — | |
| SCHEMBL7882626 | 0.67 | MAPT (0.46) | SMN1; SMN2GAAMAPTRAB9ANPC1 | |
| SCHEMBL11361086 | 0.66 | — | — | |
| SCHEMBL9475115 | 0.66 | MAPT (0.42) | SMN1; SMN2GAAMAPTHSP90AB1CYP4F2 | |
| SCHEMBL12218698 | 0.66 | DPP4 (0.40) | SMN1; SMN2GAAMAPTHSP90AB1CYP4F2 | |
| SCHEMBL873517 | 0.66 | NAMPT (0.40) | HSP90AB1CYP4F2CYP4A11HSD17B10HTT | |
| SCHEMBL3587690 | 0.66 | SMN1; SMN2 (0.46) | SMN1; SMN2GAAMAPTHSP90AB1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021156439-A1 | TRIAZOLE COMPOUNDS AS ADENOSINE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2021-08-12 | — | — | WO | disclosed |
| WO-2021156439-A1 | TRIAZOLE COMPOUNDS AS ADENOSINE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2021-08-12 | — | — | WO | disclosed |