Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 13/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | PTGFR | P43088 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | FABP3 | P05413 | 1/20 | 0.50 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373037 | 0.92 | DHODH (0.70) | DHODHCYP2C9KDM4ELMNACYP1A2 | |
| SCHEMBL2373344 | 0.91 | DHODH (0.82) | DHODHPTGFRTSHRPDE10A | |
| SCHEMBL2373435 | 0.89 | DHODH (0.57) | DHODHCYP2C9GAAKDM4ELMNA | |
| SCHEMBL2372739 | 0.88 | DHODH (0.71) | DHODHPDE10A | |
| SCHEMBL2373103 | 0.88 | DHODH (0.70) | DHODHCYP2C9ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL2372855 | 0.86 | DHODH (0.71) | DHODHPTGFRTSHRPDE10A | |
| SCHEMBL2373336 | 0.86 | DHODH (0.62) | DHODHPTGFRTSHRPDE10A | |
| SCHEMBL2373114 | 0.86 | DHODH (0.62) | DHODHPTGFRTSHRPDE10A | |
| SCHEMBL2372240 | 0.85 | DHODH (0.53) | DHODHCYP2C9ALDH1A1KDM4ELMNA | |
| SCHEMBL2373074 | 0.85 | DHODH (0.57) | DHODHCYP2C9ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |