Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.37 |
| ▸ | FYN | P06241 | 5/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23725544 | 0.85 | EPHX1 (0.38) | KDRFYNFGFR3KDM4EALDH1A1 | |
| SCHEMBL23725762 | 0.83 | CD274 (0.36) | KDRFGFR3 | |
| SCHEMBL23726341 | 0.82 | KDR (0.40) | KDRFGFR3HDAC8 | |
| SCHEMBL23725133 | 0.80 | KDR (0.42) | KDRFGFR3HDAC8KDM4EALDH1A1 | |
| SCHEMBL23726936 | 0.75 | KDR (0.40) | KDRFGFR3HDAC8KDM4EALDH1A1 | |
| SCHEMBL23727317 | 0.75 | KDM4E (0.38) | FYNKDM4EALDH1A1GLAGAA | |
| SCHEMBL30433252 | 0.72 | SSTR4 (0.42) | KDRFGFR3KDM4EALDH1A1GLA | |
| SCHEMBL23726096 | 0.72 | KDM4E (0.67) | KDRFGFR3KDM4EALDH1A1GLA | |
| SCHEMBL23726576 | 0.70 | KDR (0.43) | KDRFGFR3HDAC8KDM4EALDH1A1 | |
| SCHEMBL23725758 | 0.70 | KDR (0.44) | KDRFGFR3KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |