Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | PTGFR | P43088 | 15/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RORB | Q92753 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372319 | 0.84 | DHODH (0.54) | DHODHPTGFRKDM4ECYP1A2CYP2C9 | |
| SCHEMBL2372745 | 0.84 | PTGFR (0.61) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2372070 | 0.83 | DHODH (0.65) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2372769 | 0.82 | PTGFR (0.54) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL14553163 | 0.81 | DHODH (0.59) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2371993 | 0.81 | DHODH (0.59) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2373268 | 0.81 | DHODH (0.49) | DHODHPTGFRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2373011 | 0.81 | DHODH (0.58) | DHODHPTGFRKDM4EMEN1KMT2A | |
| SCHEMBL2461722 | 0.80 | DHODH (0.73) | DHODHPTGFR | |
| SCHEMBL2373595 | 0.80 | DHODH (0.45) | DHODHPTGFRKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |