Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | TPH1 | P17752 | 8/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23729862 | 1.00 | TTR (0.57) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL23729417 | 1.00 | TTR (0.57) | TTRALBMAOACNR1DRD1 | |
| Hydrochloric Acid SCHEMBL23704420 | 0.99 | TTR (0.56) | TTRALBMAOACNR1DRD1 | |
| Hydrochloric Acid SCHEMBL30049735 | 0.99 | TTR (0.56) | TTRALBMAOACNR1DRD1 | |
| Hydrochloric Acid SCHEMBL23704417 | 0.99 | TTR (0.56) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL23729861 | 0.90 | TTR (0.54) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL23729402 | 0.90 | TTR (0.54) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL23729392 | 0.90 | TTR (0.56) | TTRALBMAOACNR1DRD1 | |
| Hydrochloric Acid SCHEMBL23704416 | 0.89 | TTR (0.53) | TTRALBMAOACNR1DRD1 | |
| Hydrochloric Acid SCHEMBL23704414 | 0.89 | TTR (0.53) | TTRALBMAOACNR1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021154842-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | PROTEGO BIOPHARMA, INC. (US) | 2021-08-05 | — | — | WO | disclosed |