Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.36 |
| ▸ | FEN1 | P39748 | 3/20 | 0.36 |
| ▸ | SQOR | Q9Y6N5 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26116987 | 0.75 | HTT (0.38) | RECQLHTTMAPK1ALOX5APFEN1 | |
| SCHEMBL29686192 | 0.75 | HTT (0.38) | RECQLHTTMAPK1ALOX5APFEN1 | |
| SCHEMBL26546110 | 0.75 | CHEK1 (0.36) | RECQLHTTGPBAR1MAPK1ALOX5AP | |
| SCHEMBL2403919 | 0.71 | KDM1A (0.50) | RECQLGPBAR1MAPK1KDM4ECYP3A4 | |
| SCHEMBL15472079 | 0.70 | PIK3CA (0.41) | CYP3A4PIK3CAAURKAAURKBALDH1A1 | |
| SCHEMBL12093598 | 0.70 | PIK3CA (0.44) | CYP3A4PIK3CAAURKATTKAURKB | |
| SCHEMBL3570149 | 0.70 | RECQL (0.49) | RECQLHTTMAPK1CHEK1KDM4E | |
| SCHEMBL30827972 | 0.70 | CDK2 (0.40) | GPBAR1SCN9AALOX5APFEN1SQOR | |
| SCHEMBL28582907 | 0.70 | CDK2 (0.40) | GPBAR1SCN9AALOX5APFEN1SQOR | |
| SCHEMBL30828009 | 0.69 | CCNT1 (0.35) | GPBAR1SCN9APOLQPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210403485-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS SELECTIVE TRK INHIBITOR | SHANDONG LUYE PHARMACEUTICAL CO., LTD. (CN) | 2021-12-30 | — | — | US | disclosed |
| EP-3858834-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS SELECTIVE TRK INHIBITOR | Shandong Luye Pharmaceutical Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210403485-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS SELECTIVE TRK INHIBITOR | NTRK1, RET, TTK | RECQL 4089/4885HTT 1795/4885GPBAR1 1229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.