Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 6/20 | 0.37 |
| ▸ | CDK4 | P11802 | 5/20 | 0.36 |
| ▸ | CDK2 | P24941 | 5/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23733460 | 0.92 | KDM4E (0.40) | ALDH1A1CASP1CASP7KDM4EMEN1 | |
| SCHEMBL23733458 | 0.92 | KDM4E (0.40) | ALDH1A1CASP1CASP7KDM4EMEN1 | |
| SCHEMBL21414420 | 0.90 | CDK4 (0.38) | ALDH1A1CASP1CASP7KDM4EMEN1 | |
| SCHEMBL23733456 | 0.90 | KDM4E (0.43) | ALDH1A1KDM4EMEN1KDRCDK4 | |
| SCHEMBL21414440 | 0.87 | KDR (0.42) | ALDH1A1KDM4EKDRCDK4CDK2 | |
| SCHEMBL21414488 | 0.86 | KDR (0.36) | ALDH1A1CASP1CASP7KDM4EMEN1 | |
| SCHEMBL23733485 | 0.86 | KDR (0.48) | ALDH1A1KDM4EMEN1KDRCDK4 | |
| SCHEMBL23733480 | 0.86 | KDM4E (0.40) | ALDH1A1CASP1CASP7KDM4EMEN1 | |
| SCHEMBL23733481 | 0.84 | KDR (0.47) | ALDH1A1KDM4EALOX15KDRCDK4 | |
| SCHEMBL23733486 | 0.83 | KDR (0.42) | ALDH1A1KDM4EKDRCDK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11084814-B2 | Pyrido[3, 4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof | TEIJIN PHARMA LIMITED (JP) | 2021-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11084814-B2 | Pyrido[3, 4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof | CDK4, CDK6, CDK16 | ALDH1A1 964/4885CASP1 2539/4885CASP7 1816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.