Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.69 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.67 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.67 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.67 |
| ▸ | DHODH | Q02127 | 7/20 | 0.66 |
| ▸ | CA12 | O43570 | 3/20 | 0.62 |
| ▸ | CA1 | P00915 | 3/20 | 0.62 |
| ▸ | CA2 | P00918 | 3/20 | 0.62 |
| ▸ | CA9 | Q16790 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372402 | 0.90 | CA12 (0.63) | KDM4ELMNASMN1; SMN2PDE10AAKR1C3 | |
| SCHEMBL30690068 | 0.87 | DHODH (0.63) | KDM4ELMNASMN1; SMN2PDE10AAKR1C3 | |
| SCHEMBL116029 | 0.86 | DHODH (0.74) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL4246561 | 0.85 | DHODH (0.55) | KDM4ELMNASMN1; SMN2PDE10AAKR1C3 | |
| SCHEMBL10760636 | 0.84 | CA12 (0.55) | KDM4ELMNASMN1; SMN2PDE10AAKR1C3 | |
| SCHEMBL8617534 | 0.83 | CA12 (0.64) | KDM4ELMNASMN1; SMN2PDE10AAKR1C3 | |
| Cinchophen SCHEMBL25519 | 0.83 | KDM4E (1.00) | KDM4ELMNASMN1; SMN2PDE10AAKR1C3 | |
| Cinchophen SCHEMBL7588217 | 0.83 | KDM4E (1.00) | KDM4ELMNASMN1; SMN2PDE10AAKR1C3 | |
| Cinchophen SCHEMBL29376617 | 0.83 | KDM4E (1.00) | KDM4ELMNASMN1; SMN2PDE10AAKR1C3 | |
| SCHEMBL10610235 | 0.82 | CA12 (0.54) | KDM4EAKR1C3AKR1C2AKR1C1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |
| US-4711890-A | TREATMENT OF ANXIETY STATES OR OF PULMONARY, RENAL, CIRCULATORY OF CARDIOVASCULAR DISORDERS | RHONE-POULENC SANTE (FR) | 1987-12-08 | — | — | US | disclosed |
| US-4684652-A | TREATING ANXIETY OR CARDIOVASCULAR DISORDERS | RHONE-POULENC SANTE (FR) | 1987-08-04 | — | — | US | disclosed |
| US-4402961-A | Derivatives of 1-(2-,3- or 4-quinolyl)-2- or -3-(2- or 3-piperidyl or -pyrrolidinyl) ethanone or propanone, and their utilization as antiarrhythmics, anticonvulsivants and for the treatment of anxiety | PHARMINDUSTRIE (FR) | 1983-09-06 | — | — | US | disclosed |