Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 3/20 | 0.56 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.56 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | AGXT | P21549 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1877816 | 0.81 | SLC1A3 (0.55) | SLC1A1SLC1A3SLC1A2CYP1A2CYP2C19 | |
| SCHEMBL6774653 | 0.81 | TSHR (0.52) | SLC1A1SLC1A3SLC1A2CYP1A2CYP2C19 | |
| SCHEMBL13174889 | 0.79 | SLC1A3 (0.50) | SLC1A1SLC1A3SLC1A2CYP1A2CYP2C19 | |
| SCHEMBL26128246 | 0.79 | SLC1A3 (0.50) | SLC1A1SLC1A3SLC1A2CYP1A2CYP2C19 | |
| SCHEMBL2597854 | 0.79 | SLC1A3 (0.50) | SLC1A1SLC1A3SLC1A2CYP1A2CYP2C19 | |
| SCHEMBL20403336 | 0.79 | SLC1A3 (0.50) | SLC1A1SLC1A3SLC1A2CYP1A2CYP2C19 | |
| Bromide SCHEMBL29032034 | 0.79 | CA1 (0.50) | SLC1A1SLC1A3SLC1A2CYP1A2CYP2C19 | |
| SCHEMBL3655454 | 0.79 | SLC1A3 (0.53) | SLC1A1SLC1A3SLC1A2CYP1A2CYP2C19 | |
| SCHEMBL8775978 | 0.78 | SLC1A3 (0.49) | SLC1A1SLC1A3SLC1A2CYP1A2CYP2C19 | |
| SCHEMBL8775968 | 0.78 | SLC1A1 (0.53) | SLC1A1SLC1A3SLC1A2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862362-A2 | CONJUGATES OF MODIFIED ANTISENSE OLIGONUCLEOTIDES AND THEIR USE FOR MODULATING PKK EXPRESSION | Ionis Pharmaceuticals, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |