Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 11/20 | 0.39 |
| ▸ | BTK | Q06187 | 5/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19275780 | 0.83 | PIK3C3 (0.36) | GRM2 | |
| SCHEMBL21741246 | 0.80 | TEAD1 (0.36) | TEAD1BTKJAK3 | |
| SCHEMBL23545017 | 0.78 | CHRM1 (0.47) | TEAD1BTKJAK3 | |
| SCHEMBL24447202 | 0.78 | CHRM1 (0.47) | TEAD1BTKJAK3 | |
| SCHEMBL20334388 | 0.78 | TEAD1 (0.34) | TEAD1BTKJAK3 | |
| SCHEMBL24876558 | 0.77 | NR1H2 (0.41) | — | |
| SCHEMBL21565892 | 0.76 | TEAD1 (0.36) | TEAD1BTKTEAD3JAK3 | |
| SCHEMBL25840889 | 0.76 | JAK3 (0.41) | JAK3 | |
| SCHEMBL20326324 | 0.76 | TEAD1 (0.39) | TEAD1BTK | |
| SCHEMBL23583943 | 0.76 | TEAD1 (0.34) | TEAD1BTKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558955-B1 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | AMGEN INC (US) | 2021-08-11 | — | — | EP | disclosed |