Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17789639 | 0.82 | SOS1 (0.45) | SOS1SOS2 | |
| SCHEMBL27443832 | 0.78 | SOS1 (0.52) | SOS1SOS2 | |
| SCHEMBL20334424 | 0.78 | SOS1 (0.31) | SOS1SOS2 | |
| SCHEMBL25859586 | 0.77 | SOS1 (0.37) | SOS1SOS2 | |
| SCHEMBL25724486 | 0.73 | — | — | |
| SCHEMBL20334425 | 0.73 | — | — | |
| SCHEMBL24720256 | 0.72 | SOS1 (0.39) | SOS1SOS2 | |
| SCHEMBL25785222 | 0.72 | SOS1 (0.37) | SOS1SOS2 | |
| SCHEMBL25785225 | 0.72 | SOS1 (0.37) | SOS1SOS2 | |
| SCHEMBL25634055 | 0.72 | SOS1 (0.37) | SOS1SOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558955-B1 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | AMGEN INC (US) | 2021-08-11 | — | — | EP | disclosed |