Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 16/20 | 0.66 |
| ▸ | EIF2AK1 | Q9BQI3 | 4/20 | 0.64 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.64 |
| ▸ | BTK | Q06187 | 2/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868717 | 0.90 | BTK (0.68) | EIF2AK3EIF2AK1EIF2AK2LCKAURKB | |
| SCHEMBL2373837 | 0.85 | EIF2AK3 (0.74) | EIF2AK3EIF2AK1EIF2AK2LCKAURKB | |
| SCHEMBL869359 | 0.82 | EIF2AK3 (0.75) | EIF2AK3EIF2AK1EIF2AK2LCKAURKB | |
| SCHEMBL869771 | 0.80 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1EIF2AK2LCKAURKB | |
| SCHEMBL869624 | 0.79 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1EIF2AK2LCKAURKB | |
| SCHEMBL868149 | 0.79 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1EIF2AK2LCKAURKB | |
| SCHEMBL29712088 | 0.79 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1EIF2AK2LCKAURKB | |
| SCHEMBL869079 | 0.79 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1EIF2AK2LCKAURKB | |
| SCHEMBL869344 | 0.78 | EIF2AK3 (0.79) | EIF2AK3EIF2AK1EIF2AK2LCKAURKB | |
| SCHEMBL869035 | 0.78 | EIF2AK3 (0.78) | EIF2AK3EIF2AK1EIF2AK2LCKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |