Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 12/20 | 0.52 |
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | DRD3 | P35462 | 4/20 | 0.50 |
| ▸ | DRD4 | P21917 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.48 |
| ▸ | TNF | P01375 | 2/20 | 0.48 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | IL1B | P01584 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21848747 | 0.99 | CRBN (0.52) | CRBNIKZF3DRD2DRD3DRD4 | |
| SCHEMBL21848724 | 0.99 | CRBN (0.52) | CRBNIKZF3DRD2DRD3DRD4 | |
| SCHEMBL21848649 | 0.95 | CRBN (0.54) | CRBNIKZF3DRD2DDB1TNF | |
| SCHEMBL21848735 | 0.91 | CRBN (0.53) | CRBNIKZF3DRD2DDB1TNF | |
| SCHEMBL21848659 | 0.90 | CRBN (0.52) | CRBNIKZF3DRD2DDB1TNF | |
| SCHEMBL31338076 | 0.90 | CRBN (0.60) | CRBNIKZF3DRD2DDB1TNF | |
| SCHEMBL21848644 | 0.90 | CRBN (0.65) | CRBNIKZF3DRD2DDB1ADRA1D | |
| SCHEMBL21848666 | 0.89 | CRBN (0.65) | CRBNIKZF3DRD2DDB1ADRA1D | |
| SCHEMBL21848663 | 0.89 | CRBN (0.58) | CRBNIKZF3DRD2DDB1TNF | |
| SCHEMBL30388965 | 0.89 | CRBN (0.58) | CRBNIKZF3DRD2DDB1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |