Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | PTGFR | P43088 | 6/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RORB | Q92753 | 2/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | CTSA | P10619 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373266 | 0.93 | DHODH (0.47) | DHODHPTGFRABCG2KDM4EGAA | |
| SCHEMBL2372628 | 0.87 | DHODH (0.47) | DHODHPTGFRABCG2RORBKRAS | |
| SCHEMBL2372678 | 0.87 | DHODH (0.50) | DHODHPTGFRABCG2KDM4EGAA | |
| SCHEMBL2372979 | 0.86 | DHODH (0.49) | DHODHPTGFRKDM4EGAARORB | |
| SCHEMBL2373877 | 0.86 | DHODH (0.49) | DHODHPTGFRKDM4EGAARORB | |
| SCHEMBL2373268 | 0.86 | DHODH (0.49) | DHODHPTGFRKDM4ERORB | |
| SCHEMBL2372351 | 0.84 | DHODH (0.48) | DHODHPTGFRABCG2KDM4EGAA | |
| SCHEMBL2372892 | 0.84 | DHODH (0.44) | DHODHPTGFRKDM4EGAACTSA | |
| SCHEMBL2466113 | 0.84 | DHODH (0.46) | DHODHPTGFRKDM4EGAARORB | |
| SCHEMBL2373839 | 0.84 | PTGFR (0.46) | DHODHPTGFRKDM4EGAARORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |