Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 14/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 11/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26429331 | 1.00 | CHRM2 (0.57) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL23744746 | 1.00 | CHRM2 (0.57) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL26431799 | 0.94 | CHRM2 (0.53) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL26429774 | 0.92 | CHRM2 (0.48) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL26429751 | 0.92 | CHRM2 (0.50) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL26429790 | 0.91 | CHRM2 (0.46) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL23744745 | 0.90 | CHRM4 (0.54) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL26429368 | 0.90 | CHRM4 (0.54) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL26090162 | 0.90 | CHRM1 (0.47) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL31492269 | 0.89 | CHRM2 (0.45) | CHRM2CHRM1CHRM3CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100410-B1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES INC (US) | 2026-04-22 | — | — | EP | claimed |
| US-20230129359-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. | 2023-04-27 | — | — | US | claimed |
| CN-115362156-A | Muscarinic receptor 4 antagonists and methods of use | 纽罗克里生物科学有限公司 | 2022-11-18 | — | — | CN | claimed |
| EP-4100410-B1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES INC (US) | 2026-04-22 | — | — | EP | disclosed |
| US-20230129359-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. | 2023-04-27 | — | — | US | disclosed |
| US-20230129359-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. | 2023-04-27 | — | — | US | disclosed |
| US-20230129359-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. | 2023-04-27 | — | — | US | disclosed |
| CN-115362156-A | Muscarinic receptor 4 antagonists and methods of use | 纽罗克里生物科学有限公司 | 2022-11-18 | — | — | CN | disclosed |
| WO-2021158698-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230129359-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | CHRM4, CHRM2, CHRM5 | CHRM2 2/4885CHRM1 5/4885CHRM3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.