Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23744254 | 1.00 | CHRM1 (0.48) | CHRM1CHRM2HRH3CHRM4CHRM3 | |
| SCHEMBL23744252 | 0.91 | CHRM2 (0.50) | CHRM1CHRM2HRH3CHRM4CHRM3 | |
| SCHEMBL23744444 | 0.91 | CHRM2 (0.50) | CHRM1CHRM2HRH3CHRM4CHRM3 | |
| SCHEMBL23744443 | 0.87 | CHRM1 (0.51) | CHRM1CHRM2CHRM4CHRM3KCNH2 | |
| SCHEMBL26429343 | 0.86 | CHRM2 (0.41) | CHRM1CHRM2HRH3CHRM4CHRM3 | |
| SCHEMBL26429349 | 0.86 | CHRM2 (0.41) | CHRM1CHRM2HRH3CHRM4CHRM3 | |
| SCHEMBL23744446 | 0.84 | CHRM4 (0.52) | CHRM1CHRM2HRH3CHRM4CHRM3 | |
| SCHEMBL23744223 | 0.83 | CHRM2 (0.69) | CHRM1CHRM2CHRM4CHRM3CHRM5 | |
| SCHEMBL23744447 | 0.83 | CHRM2 (0.47) | CHRM1CHRM2HRH3CHRM4CHRM3 | |
| SCHEMBL23744181 | 0.83 | CHRM2 (0.61) | CHRM1CHRM2CHRM4CHRM3CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158698-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-08-12 | — | — | WO | disclosed |