Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SORD | Q00796 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23744675 | 0.80 | GRM1 (0.48) | HRH4HDAC3HDAC2HCRTR1HCRTR2 | |
| SCHEMBL23727541 | 0.77 | HCAR2 (0.50) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL26089815 | 0.77 | HCAR2 (0.50) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL23744797 | 0.76 | ACVR1 (0.47) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL23744669 | 0.76 | HCAR2 (0.47) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL23744676 | 0.76 | HCAR2 (0.47) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL23744193 | 0.74 | MEN1 (0.43) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL23744192 | 0.74 | MEN1 (0.43) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL30345676 | 0.74 | MEN1 (0.43) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL30345513 | 0.74 | MEN1 (0.43) | MEN1NPC1RAB9AKMT2AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158698-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-08-12 | — | — | WO | disclosed |