Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 6/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.51 |
| ▸ | CCR3 | P51677 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23744527 | 1.00 | CHRM4 (0.52) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL23744544 | 0.91 | HCAR2 (0.57) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL23744728 | 0.91 | HCAR2 (0.57) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL23744464 | 0.90 | CHRM2 (0.55) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL23744463 | 0.90 | CHRM2 (0.55) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL23744733 | 0.89 | KDM4E (0.52) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL23744528 | 0.89 | KDM4E (0.52) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL26087529 | 0.88 | HCAR2 (0.46) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL26089803 | 0.88 | HCAR2 (0.46) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL23744456 | 0.86 | CHRM4 (0.47) | CHRM4CHRM2CHRM1CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158698-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-08-12 | — | — | WO | disclosed |