⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5176816 | 0.79 | — | — | |
| SCHEMBL1024162 | 0.76 | — | — | |
| SCHEMBL27741881 | 0.74 | — | — | |
| SCHEMBL28025929 | 0.74 | SPHK2 (0.59) | — | |
| SCHEMBL94415 | 0.72 | — | — | |
| SCHEMBL27510380 | 0.72 | — | — | |
| SCHEMBL516399 | 0.72 | — | — | |
| SCHEMBL11231522 | 0.72 | — | — | |
| SCHEMBL27496456 | 0.72 | — | — | |
| SCHEMBL28230952 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230317700-A1 | CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME | ZYMEWORKS BC INC. (CA) | 2023-10-05 | — | — | US | disclosed |
| US-11591405-B2 | Cytotoxic and anti-mitotic compounds, and methods of using the same | ZYMEWORKS BC INC. | 2023-02-28 | — | — | US | disclosed |
| EP-4029873-A1 | CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME | Zymeworks Inc. (CA) | 2022-07-20 | — | — | EP | disclosed |
| EP-3194421-B1 | CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME | ZYMEWORKS INC (CA) | 2021-11-03 | — | — | EP | disclosed |
| EP-3087091-B1 | VAR2CSA-DRUG CONJUGATES | ZYMEWORKS INC (CA) | 2021-10-20 | — | — | EP | disclosed |
| CN-113416229-A | Cytotoxic and antimitotic compounds, and methods of use thereof | 酵活有限公司 | 2021-09-21 | — | — | CN | disclosed |
| CN-107001415-B | Cytotoxic and antimitotic compounds, and methods of use thereof | 酵活有限公司 | 2021-06-18 | — | — | CN | disclosed |
| US-20200207865-A2 | CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME | ZYMEWORKS BC INC. (CA) | 2020-07-02 | — | — | US | disclosed |
| US-10675355-B2 | VAR2CSA-drug conjugates | VAR2 PHARMACEUTICALS APS (DK) | 2020-06-09 | — | — | US | disclosed |
| US-20190345254-A1 | CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME | ZYMEWORKS INC (CA) | 2019-11-14 | — | — | US | disclosed |
| CN-1319950-C | 3-substituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORP (JP) | 2007-06-06 | — | — | CN | disclosed |
| CN-1810802-A | 3-substituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORP (JP) | 2006-08-02 | — | — | CN | disclosed |
| WO-2006049264-A1 | ETHYLENICALLY UNSATURATED GROUP-CONTAINING ISOCYANATE COMPOUND AND PROCESS FOR PRODUCING THE SAME, AND REACTIVE MONOMER, REACTIVE (METH)ACRYLATE POLYMER AND ITS USE | SHOWA DENKO K.K. (JP) | 2006-05-11 | — | — | WO | disclosed |
| CN-1764650-A | 2, 3, 6-trisubstituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORP (JP) | 2006-04-26 | — | — | CN | disclosed |
| CN-1726209-A | 3-substituted-4-pyrimidone derivatives | SANOFI AVENTIS (JP) | 2006-01-25 | — | — | CN | disclosed |
| CN-1556804-A | 3-substituted-4-pyrimidone derivatives | ������ҩ��ʽ���� | 2004-12-22 | — | — | CN | disclosed |
| CN-1555367-A | 3-substituted-4-pyrimidone derivatives | ������ҩ��ʽ���� | 2004-12-15 | — | — | CN | disclosed |
| CN-1063442-C | Aminothiazole derivatives, drug containing the same and intermediate in the production of the compounds | ZERIA PHARM CO LTD (JP) | 2001-03-21 | — | — | CN | disclosed |
| CN-1184471-A | Aminothiazole derivatives, drug containing the same and intermediate in the production of the compounds | ZERIA PHARM CO LTD (JP) | 1998-06-10 | — | — | CN | disclosed |
| CN-1045971-A | New Carbostyril derivative, their preparation method and the antiseptic-germicide that contains this analog derivative | WAKUNAGA SEIYAKU KK (JP) | 1990-10-10 | — | — | CN | disclosed |