Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 17/20 | 0.67 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868648 | 0.90 | EIF2AK3 (0.69) | EIF2AK3EIF2AK2 | |
| SCHEMBL2374671 | 0.89 | EIF2AK3 (0.66) | EIF2AK3EIF2AK2RIPK1EIF2AK1 | |
| SCHEMBL868471 | 0.89 | EIF2AK3 (0.80) | EIF2AK3EIF2AK2RIPK1EIF2AK1 | |
| SCHEMBL2374760 | 0.85 | EIF2AK3 (0.67) | EIF2AK3EIF2AK2RIPK1EIF2AK1 | |
| SCHEMBL868766 | 0.85 | EIF2AK3 (0.74) | EIF2AK3EIF2AK2RIPK1EIF2AK1 | |
| SCHEMBL868231 | 0.84 | EIF2AK3 (0.76) | EIF2AK3EIF2AK2RIPK1EIF2AK1 | |
| SCHEMBL868270 | 0.84 | EIF2AK3 (0.76) | EIF2AK3EIF2AK2RIPK1EIF2AK1 | |
| SCHEMBL869421 | 0.82 | EIF2AK3 (0.81) | EIF2AK3EIF2AK2RIPK1EIF2AK1 | |
| SCHEMBL868634 | 0.81 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2RIPK1EIF2AK1 | |
| SCHEMBL869000 | 0.81 | EIF2AK3 (0.80) | EIF2AK3EIF2AK2RIPK1EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |