⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27497190 | 0.77 | — | — | |
| SCHEMBL22652945 | 0.77 | SMPD3 (0.30) | — | |
| SCHEMBL24907460 | 0.76 | — | — | |
| SCHEMBL25019043 | 0.70 | LRRK2 (0.43) | — | |
| SCHEMBL21720842 | 0.67 | CYP17A1 (0.33) | — | |
| SCHEMBL21718834 | 0.65 | CYP1A2 (0.35) | — | |
| SCHEMBL23985317 | 0.64 | CYP17A1 (0.35) | — | |
| SCHEMBL20345213 | 0.64 | — | — | |
| SCHEMBL21719194 | 0.62 | LRRK2 (0.35) | — | |
| SCHEMBL22924785 | 0.62 | LRRK2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667634-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-20210246135-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2021-08-12 | — | — | US | disclosed |