SCHEMBL23745952

SCHEMBL23745952

Nc1ccccc1NC(=O)c1cnc(NCc2ccccc2)nc1

nearest known ligand 0.72

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 19/20 0.72
HDAC3 O15379 8/20 0.66
HDAC2 Q92769 8/20 0.66
HDAC6 Q9UBN7 5/20 0.66
HDAC8 Q9BY41 4/20 0.66
NCOR1 O75376 2/20 0.66
NCOR2 Q9Y618 2/20 0.66
VNN1 O95497 1/20 0.59
MAPK1 P28482 1/20 0.59
HDAC11 Q96DB2 3/20 0.58
HDAC4 P56524 1/20 0.58
HDAC7 Q8WUI4 1/20 0.58
HDAC10 Q969S8 1/20 0.58
HDAC9 Q9UKV0 1/20 0.58
HDAC5 Q9UQL6 1/20 0.58
CYP3A4 P08684 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1064069 0.84 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6HDAC8
SCHEMBL31141619 0.83 HDAC3 (0.77) HDAC1HDAC3HDAC2HDAC6HDAC8
SCHEMBL18086520 0.82 HDAC1 (0.62) HDAC1HDAC3HDAC2HDAC6HDAC8
SCHEMBL23746024 0.82 HDAC1 (0.90) HDAC1HDAC3HDAC2HDAC6HDAC8
SCHEMBL1063736 0.82 HDAC1 (0.87) HDAC1HDAC3HDAC2HDAC6HDAC8
SCHEMBL23745955 0.81 HDAC1 (0.72) HDAC1HDAC3HDAC2HDAC6HDAC8
SCHEMBL4730012 0.80 HDAC3 (1.00) HDAC1HDAC3HDAC2HDAC6HDAC8
SCHEMBL23746023 0.80 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6HDAC8
SCHEMBL1063174 0.79 HDAC1 (0.84) HDAC1HDAC3HDAC2HDAC6HDAC8
SCHEMBL213632 0.79 HDAC1 (0.78) HDAC1HDAC3HDAC2HDAC6HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021158869-A1 COMPOUNDS, COMPOSITIONS, METHODS FOR TREATING DISEASES AND NERVE DAMAGE, AND METHODS FOR PREPARING COMPOUNDS CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2021-08-12 WO disclosed