Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 7/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BCL6 | P41182 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 8/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | FECH | P22830 | 1/20 | 0.38 |
| ▸ | MYH14 | Q7Z406 | 1/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23747251 | 0.95 | BCL6 (0.44) | ERBB2EGFRMAPTBCL6BRAF | |
| SCHEMBL23747253 | 0.91 | BCL6 (0.50) | ERBB2EGFRMAPTBCL6NQO2 | |
| SCHEMBL26428660 | 0.86 | EGFR (0.43) | ERBB2EGFRMAPTBRAF | |
| SCHEMBL23747164 | 0.85 | ERBB2 (0.54) | ERBB2EGFRNQO2FECHMYH14 | |
| SCHEMBL30576158 | 0.85 | ERBB2 (0.54) | ERBB2EGFRNQO2FECHMYH14 | |
| SCHEMBL23957558 | 0.84 | ERBB2 (0.48) | ERBB2EGFRMAPTKDR | |
| SCHEMBL23747172 | 0.84 | EPHA2 (0.44) | ERBB2EGFRMAPTBRAFEPHA2 | |
| SCHEMBL24945023 | 0.83 | EGFR (0.48) | ERBB2EGFRMAPTBRAFNQO2 | |
| SCHEMBL27197205 | 0.83 | EGFR (0.49) | ERBB2EGFRMAPTBRAFNQO2 | |
| SCHEMBL26428661 | 0.81 | EGFR (0.41) | ERBB2EGFRMAPTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230131720-A1 | [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS | BOEHRINGER INGELHEIM RCV GMBH & CO KG (AT) | 2023-04-27 | — | — | US | disclosed |
| US-20230131720-A1 | [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS | BOEHRINGER INGELHEIM RCV GMBH & CO KG (AT) | 2023-04-27 | — | — | US | disclosed |
| WO-2021156180-A1 | [1,3]DIAZINO[5,4-D]PYRIMIDINES AS HER2 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230131720-A1 | [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS | ERBB2, ERBB3, ERBB4 | ERBB2 1/4885EGFR 4/4885MAPT 4192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.