Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23747372 | 0.85 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL26558192 | 0.83 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL26132646 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL26547229 | 0.79 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL26098498 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL26101263 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL23727723 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL17916794 | 0.78 | SMN1; SMN2 (0.88) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL23747801 | 0.78 | CCR3 (0.59) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL23747448 | 0.77 | CHRM1 (0.69) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |