Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGB1 | P09429 | 1/20 | 0.63 |
| ▸ | BID | P55957 | 4/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.53 |
| ▸ | BAK1 | Q16611 | 3/20 | 0.53 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.53 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.53 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.53 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.53 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.53 |
| ▸ | IAPP | P10997 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL22573105 | 1.00 | HMGB1 (0.63) | HMGB1BIDMCL1BCL2L1BAK1 | |
| SCHEMBL39812 | 0.98 | HMGB1 (0.65) | HMGB1BIDMCL1BCL2L1BAK1 | |
| SCHEMBL4649025 | 0.97 | HMGB1 (0.63) | HMGB1BIDMCL1BCL2L1BAK1 | |
| SCHEMBL27347887 | 0.97 | HMGB1 (0.63) | HMGB1BIDMCL1BCL2L1BAK1 | |
| SCHEMBL300854 | 0.93 | HMGB1 (0.63) | HMGB1BIDMCL1BCL2L1BAK1 | |
| SCHEMBL6435540 | 0.92 | BID (0.63) | HMGB1BIDMCL1BCL2L1BAK1 | |
| SCHEMBL2044839 | 0.92 | BID (0.63) | HMGB1BIDMCL1BCL2L1BAK1 | |
| SCHEMBL5272270 | 0.92 | BID (0.63) | HMGB1BIDMCL1BCL2L1BAK1 | |
| SCHEMBL342175 | 0.92 | BID (0.63) | HMGB1BIDMCL1BCL2L1BAK1 | |
| SCHEMBL1003208 | 0.92 | BID (0.63) | HMGB1BIDMCL1BCL2L1BAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210371609-A1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | COVESTRO LLC | 2021-12-02 | — | — | US | disclosed |
| EP-3707198-B1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | COVESTRO DEUTSCHLAND AG (DE) | 2021-10-27 | — | — | EP | disclosed |
| EP-3721292-A1 | ADHESIVE-FREE PHOTOPOLYMER LAYER STRUCTURE | Covestro Deutschland AG (DE) | 2020-10-14 | — | — | EP | disclosed |
| EP-3707198-A1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | Covestro Deutschland AG (DE) | 2020-09-16 | — | — | EP | disclosed |
| EP-3645297-A1 | IMPROVED METHOD FOR THE PARTIAL COLOURING OF PLASTIC PARTS | Covestro Deutschland AG (DE) | 2020-05-06 | — | — | EP | disclosed |
| US-10131178-B2 | Layered structure and films for ID documents having improved properties for laser engraving | COVESTRO DEUTSCHLAND AG (DE) | 2018-11-20 | — | — | US | disclosed |
| EP-2820071-B1 | PROCESS FOR THE PRODUCTION OF LOW STRESS AND OPTICAL QUALITY FILM FOR USE IN OPTO-ELECTRONIC DEVICES | COVESTRO DEUTSCHLAND AG (DE) | 2017-03-22 | — | — | EP | disclosed |
| US-9108357-B2 | Multilayer decorative film | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-08-18 | — | — | US | disclosed |
| EP-2820071-A1 | PROCESS FOR THE PRODUCTION OF LOW STRESS AND OPTICAL QUALITY FILM FOR USE IN OPTO-ELECTRONIC DEVICES | Bayer Intellectual Property GmbH (DE) | 2015-01-07 | — | — | EP | disclosed |
| EP-2694698-A1 | A PROCESS FOR MULTI-LAYER CONTINUOUS ROLL-TO-ROLL COATING | Bayer Intellectual Property GmbH (DE) | 2014-02-12 | — | — | EP | disclosed |
| EP-2508646-A1 | A process for multi-layer continuous roll-to-roll coating | Bayer Material Science AG (DE) | 2012-10-10 | — | — | EP | disclosed |
| US-8168110-B2 | Method for producing a deep-drawn film part from a thermoplastic material | BAYER MATERIALSCIENCE AG (DE) | 2012-05-01 | — | — | US | disclosed |
| US-20120001413-A1 | LAYER STRUCTURE AND FILMS FOR ID DOCUMENTS HAVING IMPROVED PROPERTIES FOR LASER ENGRAVING | BAYER MATERIALSCIENCE AG (DE) | 2012-01-05 | — | — | US | disclosed |
| US-20110193337-A1 | FORGERY-PROOF SECURITY FEATURES IN SECURITY OR VALUE DOCUMENTS | BAYER MATERIAL SCIENCE AG (DE) | 2011-08-11 | — | — | US | disclosed |
| US-20110184144-A1 | PROCESS AND APPARATUS FOR THE PREPARATION OF POLYCARBONATE | BAYER MATERIALSCIENCE AG (DE) | 2011-07-28 | — | — | US | disclosed |
| US-20100237544-A1 | METHOD FOR PRODUCING A DEEP-DRAWN FILM PART FROM A THERMOPLASTIC MATERIAL | BAYER MATERIALSCIENCE AG (DE) | 2010-09-23 | — | — | US | disclosed |
| US-7250483-B2 | Inhibition of catalytically active impurities in polycarbonate by the melt transesterification process | BAYER MATERIALSCIENCE AG (DE) | 2007-07-31 | — | — | US | disclosed |
| US-7091302-B2 | Process for the preparation of polycarbonate | BAYER MATERIALSCIENCE AG (DE) | 2006-08-15 | — | — | US | disclosed |
| US-20060004178-A1 | Inhibition of catalytically active impurities in polycarbonate by the melt transesterification process | COVESTRO DEUTSCHLAND AG (DE) | 2006-01-05 | — | — | US | disclosed |
| US-20050239995-A1 | Process for the preparation of polycarbonate | BAYER MATERIALSCIENCE AG | 2005-10-27 | — | — | US | disclosed |