Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.58 |
| ▸ | PIK3R1 | P27986 | 18/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2375589 | 0.90 | PIK3CA (0.61) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL2378874 | 0.89 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL2376411 | 0.88 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CBPIK3CDPIK3C2B | |
| SCHEMBL2379788 | 0.88 | PIK3CA (0.67) | PIK3CAPIK3R1PIK3CBMTOR | |
| SCHEMBL2378095 | 0.87 | PIK3CA (0.61) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL2378304 | 0.86 | PIK3CA (0.54) | PIK3CAPIK3R1PIK3CBPIK3CDPIK3C2B | |
| SCHEMBL2377669 | 0.86 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CBMTORPIK3CG | |
| SCHEMBL2377845 | 0.86 | PIK3CA (0.49) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2377236 | 0.85 | PIK3CA (0.50) | PIK3CAPIK3R1PIK3CBPIK3CDPIK3C2B | |
| SCHEMBL2377687 | 0.85 | PIK3CA (0.52) | PIK3CAPIK3R1PIK3CBPIK3CDPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022205-B2 | Pyrimidine derivatives as PI3K inhibitor and use thereof | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-09-20 | — | — | US | disclosed |