Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 14/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2376117 | 0.92 | PIK3CA (0.48) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2375640 | 0.92 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL2378088 | 0.90 | PIK3CA (0.56) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2378360 | 0.85 | PIK3CA (0.48) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL2375589 | 0.84 | PIK3CA (0.61) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL2378924 | 0.84 | PIK3CA (0.51) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2377416 | 0.84 | PIK3CA (0.57) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2379788 | 0.84 | PIK3CA (0.67) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2377842 | 0.83 | PIK3CA (0.56) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL2392322 | 0.83 | PIK3CA (0.63) | PIK3CAPIK3R1PIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022205-B2 | Pyrimidine derivatives as PI3K inhibitor and use thereof | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-09-20 | — | — | US | disclosed |