Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.78 |
| ▸ | JAK1 | P23458 | 20/20 | 0.78 |
| ▸ | TYK2 | P29597 | 20/20 | 0.78 |
| ▸ | JAK3 | P52333 | 9/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23424223 | 1.00 | JAK2 (0.78) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757115 | 0.93 | JAK2 (0.78) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757007 | 0.87 | JAK2 (1.00) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757091 | 0.87 | JAK2 (1.00) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757092 | 0.87 | JAK2 (1.00) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757056 | 0.87 | JAK2 (1.00) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757005 | 0.83 | JAK2 (1.00) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757107 | 0.83 | JAK2 (1.00) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757032 | 0.82 | JAK2 (1.00) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757089 | 0.82 | JAK2 (1.00) | JAK2JAK1TYK2JAK3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021159372-A1 | USE OF JAK INHIBITORS IN PREPARATION OF DRUGS FOR TREATING JAK KINASE-RELATED DISEASES | 珠海联邦制药股份有限公司 | 2021-08-19 | — | — | WO | disclosed |