SCHEMBL23768542

SCHEMBL23768542

CC(C)(C)OC(=O)CCOCCOCCOCCOCCOc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 12/20 0.56
DDB1 Q16531 10/20 0.56
MAPT P10636 2/20 0.49
LRRK2 Q5S007 1/20 0.47
ALDH1A1 P00352 1/20 0.47
CHRM2 P08172 1/20 0.47
OPRM1 P35372 1/20 0.47
IKZF3 Q9UKT9 1/20 0.47
CYP1A2 P05177 1/20 0.47
TSHR P16473 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
BRD9 Q9H8M2 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29227667 0.94 CRBN (0.60) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL30275730 0.91 CRBN (0.58) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL26147998 0.91 CRBN (0.58) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL30822413 0.91 CRBN (0.55) CRBNDDB1MAPT
SCHEMBL29227511 0.91 CRBN (0.55) CRBNDDB1MAPT
SCHEMBL30919542 0.90 CRBN (0.57) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL30783314 0.90 CRBN (0.56) CRBNDDB1MAPTBRD9
SCHEMBL30001358 0.88 CRBN (0.61) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL23729948 0.88 CRBN (0.61) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL22276609 0.87 CRBN (0.70) CRBNDDB1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021162493-A1 PROTEIN KINASE DEGRADATION INDUCING COMPOUND, AND USE THEREOF 보로노이 주식회사 2021-08-19 WO disclosed