Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PPM1B | O75688 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23419884 | 1.00 | MAPT (0.42) | MAPTPKMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28357350 | 1.00 | MAPT (0.42) | MAPTPKMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12930960 | 0.88 | MAPT (0.46) | MAPTPKMCA12CA1CA2 | |
| SCHEMBL852591 | 0.88 | MAPT (0.46) | MAPTPKMCA12CA1CA2 | |
| SCHEMBL852590 | 0.88 | MAPT (0.46) | MAPTPKMCA12CA1CA2 | |
| SCHEMBL18308315 | 0.84 | MAPT (0.56) | MAPTPKMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15202778 | 0.84 | MAPT (0.52) | MAPTPKMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21866134 | 0.84 | MAPT (0.56) | MAPTPKMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13406363 | 0.84 | MAPT (0.56) | MAPTPKMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1933511 | 0.84 | MAPT (0.52) | MAPTPKMNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023242598-A1 | BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2023-12-21 | — | — | WO | disclosed |
| EP-3630772-B1 | METHODS OF MAKING AND USING PDE9 INHIBITORS | IMARA INC (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3865484-A1 | PDE9 INHIBITOR WITH IMIDAZO PYRAZINONE BACKBONE FOR TREATMENT OF PERIPHERAL DISEASES | H. Lundbeck A/S (DK) | 2021-08-18 | — | — | EP | disclosed |