Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23768949 | 0.87 | KLKB1 (0.53) | KLKB1 | |
| SCHEMBL24919158 | 0.85 | KLKB1 (0.52) | KLKB1 | |
| SCHEMBL23754099 | 0.84 | KLKB1 (0.51) | KLKB1 | |
| SCHEMBL31357806 | 0.84 | KLKB1 (0.51) | KLKB1 | |
| SCHEMBL24918819 | 0.83 | KLKB1 (0.48) | KLKB1 | |
| SCHEMBL23768933 | 0.81 | KLKB1 (0.46) | KLKB1 | |
| SCHEMBL23769558 | 0.79 | KLKB1 (0.62) | KLKB1 | |
| SCHEMBL24918413 | 0.78 | KLKB1 (0.46) | KLKB1 | |
| SCHEMBL24105343 | 0.77 | KLKB1 (0.53) | KLKB1 | |
| SCHEMBL23769527 | 0.76 | KLKB1 (0.61) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |