Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23843083 | 1.00 | BTK (0.47) | BTKKLKB1PIK3CAP2RY12 | |
| SCHEMBL18816474 | 0.90 | BTK (0.56) | BTKKLKB1PIK3CA | |
| SCHEMBL18815275 | 0.86 | BTK (0.57) | BTKKLKB1 | |
| SCHEMBL23769232 | 0.86 | BTK (0.47) | BTKKLKB1 | |
| SCHEMBL23754006 | 0.83 | KLKB1 (0.48) | BTKKLKB1 | |
| SCHEMBL18795038 | 0.82 | BTK (0.52) | BTKKLKB1 | |
| SCHEMBL23769685 | 0.82 | BTK (0.39) | BTKKLKB1 | |
| SCHEMBL23769320 | 0.81 | NOTUM (0.42) | BTKKLKB1P2RY12 | |
| SCHEMBL23469581 | 0.80 | KLKB1 (0.56) | BTKKLKB1 | |
| SCHEMBL20540770 | 0.80 | KLKB1 (0.57) | BTKKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |