Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 15/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23843094 | 1.00 | KLKB1 (0.48) | KLKB1RBP4BTKUSP30KDM4E | |
| SCHEMBL23769331 | 0.90 | KLKB1 (0.49) | KLKB1RBP4BTKUSP30KDM4E | |
| SCHEMBL21736742 | 0.88 | KLKB1 (0.51) | KLKB1KDM4E | |
| SCHEMBL23769644 | 0.88 | KLKB1 (0.48) | KLKB1RBP4BTKUSP30KDM4E | |
| SCHEMBL23769228 | 0.87 | KLKB1 (0.47) | KLKB1RBP4BTK | |
| SCHEMBL31357813 | 0.87 | KLKB1 (0.48) | KLKB1KDM4E | |
| SCHEMBL23754036 | 0.87 | KLKB1 (0.48) | KLKB1KDM4E | |
| SCHEMBL23768864 | 0.86 | KLKB1 (0.45) | KLKB1RBP4BTKUSP30 | |
| SCHEMBL23769169 | 0.86 | KLKB1 (0.48) | KLKB1RBP4KDM4EPLA2G4A | |
| SCHEMBL23769624 | 0.86 | KLKB1 (0.62) | KLKB1RBP4BTKUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |