Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 8/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23843030 | 0.89 | KLKB1 (0.62) | KLKB1NOTUMALDH1A1MEN1KMT2A | |
| SCHEMBL23769202 | 0.83 | BTK (0.42) | KLKB1NOTUMKDM4E | |
| SCHEMBL21736655 | 0.83 | KLKB1 (0.47) | KLKB1NOTUM | |
| SCHEMBL23769320 | 0.81 | NOTUM (0.42) | KLKB1NOTUMKMT2AP2RY12LMNA | |
| SCHEMBL26309179 | 0.81 | KLKB1 (0.38) | KLKB1NOTUMALDH1A1MEN1KMT2A | |
| SCHEMBL30414959 | 0.81 | KLKB1 (0.38) | KLKB1NOTUMALDH1A1MEN1KMT2A | |
| SCHEMBL23754197 | 0.81 | KLKB1 (0.38) | KLKB1NOTUMALDH1A1MEN1KMT2A | |
| SCHEMBL23769211 | 0.80 | KLKB1 (0.38) | KLKB1NOTUMALDH1A1ALOX15KDM4E | |
| SCHEMBL23769281 | 0.79 | KLKB1 (0.45) | KLKB1NOTUM | |
| SCHEMBL23754033 | 0.79 | KLKB1 (0.46) | KLKB1NOTUMALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |