Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2377156 | 1.00 | HDAC6 (0.76) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12243818 | 0.86 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2376456 | 0.86 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2376709 | 0.83 | HDAC6 (0.78) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2376704 | 0.83 | HDAC6 (0.78) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL833494 | 0.78 | HDAC6 (0.47) | HDAC6TTRAPPPTPN1BCHE | |
| SCHEMBL833493 | 0.78 | HDAC6 (0.47) | HDAC6TTRAPPPTPN1BCHE | |
| SCHEMBL2377251 | 0.77 | HDAC6 (0.81) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2377248 | 0.77 | HDAC6 (0.81) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29913987 | 0.73 | APP (0.73) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921424-B2 | Histone deacetylase inhibitors, process for preparation and uses thereof | ZHEJIANG HISUN PHARMACEUTICAL CO. LTD. (CN) | 2014-12-30 | — | — | US | disclosed |
| EP-2208721-B1 | HISTONE DEACETYLASE INHIBITOR, COMPOSITION AND USE THEREOF | ZHEJIANG HISUN PHARM CO LTD (CN) | 2013-12-25 | — | — | EP | disclosed |
| US-20110218221-A1 | NOVEL HISTONE DEACETYLASE INHIBITORS, PROCESS FOR PREPARATION AND USES THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2011-09-08 | — | — | US | disclosed |
| EP-2208721-A1 | HISTONE DEACETYLASE INHIBITOR, COMPOSITION AND USE THEREOF | Zhejiang Hisun Pharmaceutical Co. Ltd. (CN) | 2010-07-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218221-A1 | NOVEL HISTONE DEACETYLASE INHIBITORS, PROCESS FOR PREPARATION AND USES THEREOF | HDAC1, HDAC5, HDAC11 | HDAC6 11/4885HDAC3 10/4885HDAC4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.