Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 3/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 4/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.30 |
| ▸ | APAF1 | O14727 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | CASP9 | P55211 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28916334 | 0.90 | HRH4 (0.36) | RAF1BRAFPDE3BPDE3APIM1 | |
| Hydrochloric Acid SCHEMBL23779120 | 0.89 | HRH4 (0.36) | RAF1BRAFPDE3BPDE3APIM1 | |
| SCHEMBL24321157 | 0.74 | PIP5K1C (0.45) | GSK3BWNT1DYRK1ANAMPT | |
| Hydrochloric Acid SCHEMBL23779106 | 0.73 | PIP5K1C (0.44) | GSK3BWNT1DYRK1ANAMPT | |
| SCHEMBL23779045 | 0.70 | NR1H2 (0.38) | NAMPT | |
| Trifluoroacetic Acid SCHEMBL30755785 | 0.69 | PDCD1 (0.38) | HRH4L3MBTL1 | |
| SCHEMBL23779053 | 0.66 | POLB (0.47) | HRH4NAMPT | |
| Trifluoroacetic Acid SCHEMBL29931206 | 0.66 | SCD (0.37) | HRH4L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL25410106 | 0.66 | PDCD1 (0.38) | HRH4L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL29888231 | 0.66 | PDCD1 (0.36) | HRH4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3873910-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2021-09-08 | — | — | EP | disclosed |