Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23779040 | 0.84 | HRH4 (0.47) | HRH4GRM5FLT3 | |
| SCHEMBL23779098 | 0.78 | HRH4 (0.56) | HRH4AKR1C3HRH3POLBSMN1; SMN2 | |
| SCHEMBL29519285 | 0.78 | HRH4 (0.56) | HRH4AKR1C3HRH3POLBSMN1; SMN2 | |
| SCHEMBL24319821 | 0.77 | POLB (0.39) | HRH4AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL23779097 | 0.76 | AKR1C3 (0.40) | HRH4AKR1C3POLBSMN1; SMN2GRM5 | |
| SCHEMBL29465496 | 0.73 | HRH4 (0.55) | HRH4AKR1C3HRH3POLBSMN1; SMN2 | |
| SCHEMBL22615154 | 0.73 | HRH4 (0.55) | HRH4AKR1C3HRH3POLBSMN1; SMN2 | |
| SCHEMBL22395853 | 0.72 | SCN4A (0.53) | HRH4AKR1C3HRH3POLBSMN1; SMN2 | |
| Potassium Ion SCHEMBL22615265 | 0.72 | HRH4 (0.54) | HRH4AKR1C3HRH3POLBSMN1; SMN2 | |
| Potassium Ion SCHEMBL29465485 | 0.72 | HRH4 (0.54) | HRH4AKR1C3HRH3POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3873910-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2021-09-08 | — | — | EP | disclosed |