Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319834 | 0.90 | HDAC6 (0.47) | HDAC6HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL23779139 | 0.90 | HDAC6 (0.47) | HDAC6HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL23779063 | 0.88 | HDAC6 (0.45) | HDAC6HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL24319981 | 0.86 | HDAC6 (0.43) | HDAC6HRH4HRH3AKR1C3NAMPT | |
| SCHEMBL23779113 | 0.85 | HRH4 (0.39) | HDAC6HRH4DRD3DRD2 | |
| SCHEMBL23779138 | 0.84 | HDAC6 (0.45) | HDAC6HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL24319827 | 0.84 | HDAC6 (0.48) | HDAC6HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL23779107 | 0.83 | HRH4 (0.53) | HDAC6HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL23779072 | 0.83 | POLB (0.46) | HDAC6HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL24319833 | 0.82 | HDAC6 (0.49) | HDAC6HRH4HRH3POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3873910-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2021-09-08 | — | — | EP | disclosed |