Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAD | Q92934 | 11/20 | 0.76 |
| ▸ | BCL2 | P10415 | 7/20 | 0.76 |
| ▸ | MCL1 | Q07820 | 10/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 8/20 | 0.53 |
| ▸ | PMAIP1 | Q13794 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23781461 | 0.94 | BAD (0.85) | BADBCL2MCL1BCL2L1PMAIP1 | |
| SCHEMBL23786308 | 0.93 | BAD (0.73) | BADBCL2MCL1BCL2L1 | |
| SCHEMBL23786347 | 0.92 | BAD (0.89) | BADBCL2MCL1BCL2L1PMAIP1 | |
| SCHEMBL23776523 | 0.89 | BAD (0.74) | BADBCL2MCL1BCL2L1PMAIP1 | |
| SCHEMBL23786303 | 0.88 | BAD (0.89) | BADBCL2MCL1BCL2L1 | |
| SCHEMBL22436901 | 0.87 | BAD (0.82) | BADBCL2MCL1BCL2L1 | |
| SCHEMBL22436883 | 0.86 | BAD (1.00) | BADBCL2MCL1BCL2L1PMAIP1 | |
| SCHEMBL23776994 | 0.84 | BAD (0.67) | BADBCL2MCL1BCL2L1PMAIP1 | |
| SCHEMBL19635212 | 0.84 | BAD (0.60) | BADBCL2MCL1BCL2L1PMAIP1 | |
| SCHEMBL22439661 | 0.83 | BAD (0.83) | BADBCL2MCL1BCL2L1PMAIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11478451-B1 | Macrocyclic chlorine substituted indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2022-10-25 | — | — | US | disclosed |
| US-11447504-B2 | Macrocyclic chlorine substituted indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2022-09-20 | — | — | US | disclosed |
| US-20210277022-A1 | MACROCYCLIC CHLORINE SUBSTITUTED INDOLE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447504-B2 | Macrocyclic chlorine substituted indole derivatives | CCNT2, CCNL2, CCND2 | BAD 333/4885BCL2 430/4885MCL1 26/4885 |
| US-20210277022-A1 | MACROCYCLIC CHLORINE SUBSTITUTED INDOLE DERIVATIVES | CCNT2, CCNL2, CCND2 | BAD 333/4885BCL2 430/4885MCL1 26/4885 |
| US-11478451-B1 | Macrocyclic chlorine substituted indole derivatives | CCNT2, CCNL2, CCND2 | BAD 333/4885BCL2 430/4885MCL1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.