Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2377877 | 0.97 | PIK3CA (0.53) | PIK3CAPIK3R1PIK3CBLMNAMTOR | |
| SCHEMBL2392322 | 0.89 | PIK3CA (0.63) | PIK3CAPIK3R1PIK3CBSMN1; SMN2 | |
| SCHEMBL2377842 | 0.89 | PIK3CA (0.56) | PIK3CAPIK3R1PIK3CBSMN1; SMN2 | |
| SCHEMBL2378088 | 0.89 | PIK3CA (0.56) | PIK3CAPIK3R1PIK3CBALDH1A1 | |
| SCHEMBL2378334 | 0.87 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CBMTORPIK3CG | |
| SCHEMBL2377227 | 0.87 | PIK3CA (0.61) | PIK3CAPIK3R1PIK3CBMTORPIK3CG | |
| SCHEMBL2376987 | 0.86 | PIK3CA (0.69) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2378397 | 0.85 | PIK3CA (0.67) | PIK3CAPIK3R1MEN1RAB9AKMT2A | |
| SCHEMBL2379435 | 0.85 | PIK3CA (0.63) | PIK3CAPIK3R1PIK3CBSMN1; SMN2 | |
| SCHEMBL2377779 | 0.85 | PIK3CA (0.70) | PIK3CAPIK3R1PIK3CBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022205-B2 | Pyrimidine derivatives as PI3K inhibitor and use thereof | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-09-20 | — | — | US | disclosed |