⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL600393 | 0.76 | — | — | |
| SCHEMBL29519655 | 0.48 | — | — | |
| SCHEMBL17878214 | 0.48 | NQO1 (0.32) | — | |
| SCHEMBL11846290 | 0.48 | — | — | |
| SCHEMBL22000060 | 0.48 | — | — | |
| SCHEMBL7802091 | 0.46 | — | — | |
| SCHEMBL5533417 | 0.43 | — | — | |
| SCHEMBL29525411 | 0.41 | KDM4E (0.40) | — | |
| SCHEMBL29525891 | 0.41 | KDM4E (0.40) | — | |
| SCHEMBL1309228 | 0.35 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2261203-B1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARING PROCESSES AND THE USES THEREOF | BEIJING YINGU CENTURY PHARMACY CO LTD (CN) | 2016-05-25 | — | — | EP | disclosed |
| US-8673981-B2 | Phenylcyclobutylamide derivatives and their stereoisomers, the preparation processes and uses thereof | YinGu Pharmaceutical Co., Ltd (CN) | 2014-03-18 | — | — | US | disclosed |
| US-20130289124-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARATION PROCESSES AND USES THEREOF | YinGu Pharmaceutical Co., Ltd (CN) | 2013-10-31 | — | — | US | disclosed |
| US-8497305-B2 | Phenylcyclobutylamide derivatives and their stereoisomers, the preparation processes and uses thereof | YinGu Pharmaceutical Co., Ltd (CN) | 2013-07-30 | — | — | US | disclosed |
| US-20110224305-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARATION PROCESSES AND USES THEREOF | BEIJING YINGU CENTURY PHARMACY CO. LTD (CN) | 2011-09-15 | — | — | US | disclosed |
| EP-2261203-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARING PROCESSES AND THE USES THEREOF | Beijing Cachet Biomedical Co., Ltd (CN) | 2010-12-15 | — | — | EP | disclosed |