Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.30 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | AKT2 | P31751 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2755166 | 0.78 | NPC1 (0.51) | FYNKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL239025 | 0.76 | FYN (0.38) | FYNKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL237906 | 0.74 | AKT1 (0.38) | FYNKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL235071 | 0.73 | NPC1 (0.36) | FYNKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL236782 | 0.69 | NPC1 (0.35) | KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL236328 | 0.67 | NPC1 (0.52) | FYNKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL235020 | 0.67 | NPC1 (0.54) | KDM4ENPC1RAB9ASMN1; SMN2DPP4 | |
| SCHEMBL2755214 | 0.66 | NPC1 (0.61) | FYNKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL238744 | 0.65 | NPC1 (0.36) | FYNKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL235072 | 0.65 | NPC1 (0.43) | FYNKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CD, PIK3CA, PIK3R5 | SLC6A2 3138/4885HTR2A 3819/4885HTR2C 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.