SCHEMBL23794875

SCHEMBL23794875

Cn1ccc(Nc2cccc(O)c2)n1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.57
CYP3A4 P08684 2/20 0.49
TSHR P16473 1/20 0.49
SYK P43405 3/20 0.48
RAPGEF4 Q8WZA2 1/20 0.46
ABCG2 Q9UNQ0 1/20 0.46
MAPT P10636 2/20 0.44
TP53 P04637 2/20 0.44
ALDH1A1 P00352 3/20 0.44
LMNA P02545 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
CYP1A2 P05177 2/20 0.43
USP2 O75604 1/20 0.43
APP P05067 1/20 0.43
HSP90AA1 P07900 1/20 0.43
HSP90AB1 P08238 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9820200 0.80 NPC1 (0.46) HDAC6MAPTALDH1A1LMNASMN1; SMN2
SCHEMBL12507458 0.78 KMT2A (0.62) HDAC6RAPGEF4ABCG2MAPTTP53
SCHEMBL1317961 0.73 HDAC6 (1.00) HDAC6CYP3A4TSHRSYKRAPGEF4
SCHEMBL12579765 0.73 NPC1 (0.75) ALDH1A1LMNASMN1; SMN2NPC1RAB9A
SCHEMBL30026816 0.72 CYP3A4 (0.86) HDAC6CYP3A4TSHRSYKRAPGEF4
SCHEMBL1389429 0.72 CYP3A4 (0.86) HDAC6CYP3A4TSHRSYKRAPGEF4
SCHEMBL1318150 0.71 HDAC6 (0.62) HDAC6CYP3A4TSHRSYKRAPGEF4
SCHEMBL1319475 0.70 TP53 (0.71) HDAC6CYP3A4TSHRSYKRAPGEF4
SCHEMBL23794884 0.70 NPC1 (0.54) HDAC6RAPGEF4MAPTTP53ALDH1A1
SCHEMBL13302358 0.70 CYP3A4 (0.82) HDAC6CYP3A4TSHRSYKRAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3876933-A1 NEUTROPHIL INFLAMMATION INHIBITOR AND USES THEREOF Chang Gung University of Science and Technology (TW) 2021-09-15 EP disclosed