Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.77 |
| ▸ | JAK1 | P23458 | 20/20 | 0.77 |
| ▸ | TYK2 | P29597 | 20/20 | 0.77 |
| ▸ | JAK3 | P52333 | 20/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17816035 | 0.87 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17801121 | 0.84 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL19713678 | 0.81 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17815947 | 0.81 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17815946 | 0.81 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17801289 | 0.81 | JAK2 (0.74) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17801292 | 0.81 | JAK2 (0.74) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17801291 | 0.81 | JAK2 (0.74) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17815990 | 0.80 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL19713641 | 0.80 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3878451-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A JAK-INHIBITING 4,6-SUBSTITUTED-PYRAZOLO[1,5-A]PYRAZINE COMPOUND | Array Biopharma Inc. (US) | 2021-09-15 | — | — | EP | disclosed |