Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CHRND | Q07001 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30179321 | 0.86 | CYP2D6 (0.49) | OPRM1CYP2D6OPRL1 | |
| SCHEMBL23778360 | 0.84 | DPP4 (0.47) | DPP4DPP8DPP9KMT2ASLC6A2 | |
| SCHEMBL5758344 | 0.81 | KMT2A (0.66) | KMT2AOPRM1OPRL1 | |
| SCHEMBL20066010 | 0.81 | MEN1 (0.51) | DPP4DPP8DPP9KMT2ASLC6A2 | |
| SCHEMBL5475853 | 0.79 | KMT2A (0.75) | KMT2AOPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23798663 | 0.79 | CCR1 (0.41) | KMT2AOPRM1CCR1OPRL1 | |
| SCHEMBL5475847 | 0.79 | KMT2A (0.75) | KMT2AOPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23798652 | 0.78 | DPP4 (0.42) | DPP4DPP8DPP9KMT2AOPRM1 | |
| SCHEMBL23778249 | 0.77 | CYP2D6 (0.43) | DPP4DPP8DPP9KMT2ACYP2D6 | |
| SCHEMBL23798593 | 0.76 | CYP2D6 (0.47) | DPP4DPP8DPP9KMT2ACCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526207-B1 | HETEROCYCLIC COMPOUNDS HAVING ACTIVITY AS MODULATORS OF MUSCARINIC M1 AND/OR M4 RECEPTORS IN THE TREATMENT OF CNS DISEASES AND PAINS. | HEPTARES THERAPEUTICS LTD (GB) | 2021-09-08 | — | — | EP | disclosed |