Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | DHPS | P49366 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26581453 | 0.85 | KDM4E (0.52) | KDM4ECNR2CNR1USP2LMNA | |
| SCHEMBL23809352 | 0.77 | KDM4E (0.43) | KDM4ETSHRALDH1A1CHRM1 | |
| SCHEMBL23809103 | 0.76 | KDM4E (0.42) | KDM4ELMNATSHRALDH1A1L3MBTL1 | |
| SCHEMBL23809280 | 0.73 | CNR1 (0.45) | KDM4ECNR2CNR1TSHRALDH1A1 | |
| SCHEMBL2040903 | 0.72 | CNR2 (0.46) | KDM4ECNR2CNR1USP2LMNA | |
| SCHEMBL23809203 | 0.72 | SLC22A12 (0.52) | KDM4ECNR2CNR1LMNAADRA1D | |
| SCHEMBL26581458 | 0.72 | CNR1 (0.48) | KDM4ECNR2CNR1LMNAALDH1A1 | |
| SCHEMBL23809344 | 0.71 | NOTUM (0.40) | KDM4ELMNATSHRALDH1A1L3MBTL1 | |
| SCHEMBL31023004 | 0.71 | MCL1 (0.38) | KDM4EALDH1A1CHRM1 | |
| SCHEMBL4638529 | 0.70 | KDM4E (0.46) | KDM4ECNR2CNR1USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | KDM4E 1156/4885CNR2 3259/4885CNR1 2722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.