Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 8/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | ICMT | O60725 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809512 | 0.88 | MCL1 (0.48) | MCL1PTGER4RIPK1CNR1 | |
| SCHEMBL26581596 | 0.87 | MCL1 (0.47) | MCL1PTGER4ICMTCNR1DYRK1A | |
| SCHEMBL20605018 | 0.87 | MCL1 (0.44) | MCL1PTGER4RIPK1ICMTCNR1 | |
| SCHEMBL23809288 | 0.83 | MCL1 (0.43) | MCL1RIPK1ICMTDYRK1A | |
| SCHEMBL23809509 | 0.83 | MCL1 (0.44) | MCL1PTGER4ICMT | |
| SCHEMBL23809526 | 0.81 | MCL1 (0.49) | MCL1CNR1 | |
| SCHEMBL20604942 | 0.81 | MCL1 (0.46) | MCL1CNR1 | |
| SCHEMBL26581589 | 0.79 | MCL1 (0.48) | MCL1PTGER4DYRK1A | |
| SCHEMBL23799369 | 0.79 | MCL1 (0.39) | MCL1PTGER4RIPK1CNR1DYRK1A | |
| SCHEMBL23809421 | 0.78 | DYRK1A (0.40) | MCL1CNR1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | MCL1 1/4885PTGER4 4727/4885RIPK1 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.