Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26109545 | 0.80 | KRAS (0.34) | BTKHDAC4SYK | |
| SCHEMBL30064070 | 0.80 | KRAS (0.34) | BTKHDAC4SYK | |
| SCHEMBL26109541 | 0.80 | KRAS (0.34) | BTKHDAC4SYK | |
| SCHEMBL26110984 | 0.71 | KRAS (0.33) | BTKGPR119HDAC4 | |
| SCHEMBL30063513 | 0.71 | KRAS (0.33) | BTKGPR119HDAC4 | |
| SCHEMBL23816067 | 0.71 | KRAS (0.33) | BTKGPR119HDAC4 | |
| SCHEMBL25670262 | 0.69 | KIT (0.39) | BTK | |
| SCHEMBL23816316 | 0.68 | BTK (0.38) | BTKSYK | |
| Hydrochloric Acid SCHEMBL30064702 | 0.68 | BTK (0.38) | BTKSYK | |
| Hydrochloric Acid SCHEMBL26114064 | 0.68 | BTK (0.38) | BTKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021180103-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-09-16 | — | — | WO | disclosed |